Impact of Arrhythmia on Myocardial Perfusion: A Computational Model-Based Study

(1) Background: Arrhythmia, which is an umbrella term for various types of abnormal rhythms heartbeat, has a high prevalence in both the general population and patients with coronary artery disease. So far, it remains unclear how different arrhythmia would affect myocardial perfusion risk/severity ischemia. (2) Methods: A computational model circulation coupled to global cardiovascular system was employed quantify impacts its combination disease on perfusion. Furthermore, supply–demand balance index (MSDBx) proposed quantitatively evaluate severity ischemia under arrhythmic conditions. (3) Results: Tachycardia severe irregularity heart rates (HRs) depressed increased risk subendocardial (evaluated by MSDBx), whereas lowering HR improved The presence moderate stenosis considerably augmented sensitivity MSDBx arrhythmia. Further data analyses revealed that induced mainly via reducing amount blood flow each individual cardiac cycle rather than increasing metabolic demand myocardium (measured left ventricular pressure-volume area). (4) Conclusions: Both tachycardia irregular heartbeat tend increase ischemia, especially subendocardium, effects can be further enhanced concomitant existence In contrast, properly using drugs like ?-blockers may improve perfusion, thereby preventing or relieving